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1

Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS

Bravo-Hernandez, Mariana, Tadokoro, Takahiro, Navarro, Michael R., Platoshyn, Oleksandr, Kobayashi, Yoshiomi, Marsala, Silvia, Miyanohara, Atsushi, Juhas, Stefan, Juhasova, Jana, Skalnikova, Helena, T

Journal:

Nature Medicine

Year:

2019

File:

PDF, 20.26 MB

2019

2

Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS

Bravo-Hernandez, Mariana, Tadokoro, Takahiro, Navarro, Michael R., Platoshyn, Oleksandr, Kobayashi, Yoshiomi, Marsala, Silvia, Miyanohara, Atsushi, Juhas, Stefan, Juhasova, Jana, Skalnikova, Helena, T

Journal:

Nature Medicine

Year:

2019

Language:

english

File:

PDF, 20.26 MB

english, 2019

3

Dynamics of α-synuclein aggregation and inhibition of pore-like oligomer development by β-synuclein

Igor F. Tsigelny, Pazit Bar-On, Yuriy Sharikov, Leslie Crews, Makoto Hashimoto, Mark A. Miller, Steve H. Keller, Oleksandr Platoshyn, Jason X.-J. Yuan, Eliezer Masliah

Journal:

Year:

2007

Language:

english

File:

PDF, 985 KB

english, 2007

4

Hypoxia Selectively Inhibits KCNA5 Channels in Pulmonary Artery Smooth Muscle Cells

Amy L. Firth, Oleksandr Platoshyn, Elena E. Brevnova, Elyssa D. Burg, Frank Powell, Gabriel H. Haddad, Jason X.-J. Yuan

Journal:

Annals of the New York Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 483 KB

english, 2009

5

Inhibition of endogenous TRP1 decreases capacitative Ca 2+ entry and attenuates pulmonary artery smooth muscle cell proliferation

Sweeney, Michele, Yu, Ying, Platoshyn, Oleksandr, Zhang, Shen, McDaniel, Sharon S., Yuan, Jason X.-J.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2002

Language:

english

File:

PDF, 364 KB

english, 2002

6

High K + -induced membrane depolarization attenuates endothelium-dependent pulmonary vasodilation

Seiden, Jan E., Platoshyn, Oleksandr, Bakst, Alan E., McDaniel, Sharon S., Yuan, Jason Xiao-Jian

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2000

File:

PDF, 101 KB

2000

7

Characterization of agonist-induced vasoconstriction in mouse pulmonary artery

Xu, M., Platoshyn, O., Makino, A., Dillmann, W. H., Akassoglou, K., Remillard, C. V., Yuan, J. X.-J.

Journal:

AJP Heart and Circulatory Physiology

Year:

2007

Language:

english

File:

PDF, 1.15 MB

english, 2007

8

Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns

Burg, E. D., Platoshyn, O., Tsigelny, I. F., Lozano-Ruiz, B., Rana, B. K., Yuan, J. X.-J.

Journal:

AJP Cell Physiology

Year:

2010

Language:

english

File:

PDF, 3.52 MB

english, 2010

9

Role of K + channel expression in polyamine-dependent intestinal epithelial cell migration

Wang, Jian-Ying, Wang, Jian, Golovina, Vera A., Li, Li, Platoshyn, Oleksandr, Yuan, Jason Xiao-Jian

Journal:

American journal of physiology. Cell physiology

Year:

2000

Language:

english

File:

PDF, 554 KB

english, 2000

10

Nitric oxide induces apoptosis by activating K + channels in pulmonary vascular smooth muscle cells

Krick, Stefanie, Platoshyn, Oleksandr, Sweeney, Michele, McDaniel, Sharon S., Zhang, Shen, Rubin, Lewis J., Yuan, Jason X.-J.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2002

Language:

english

File:

PDF, 597 KB

english, 2002

11

Heterogeneity of hypoxia-mediated decrease in IK(V) and increase in [Ca2+]cyt in pulmonary artery smooth muscle cells

Platoshyn, O., Yu, Y., Ko, E. A, Remillard, C. V., Yuan, J. X.-J.

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2007

Language:

english

File:

PDF, 957 KB

english, 2007

12

Survival and Differentiation of Human Embryonic Stem Cell-Derived Neural Precursors Grafted Spinally in Spinal Ischemia-Injured Rats or in Naive Immunosuppressed Minipigs: A Qualitative and Quantitative Study

Kakinohana, O., Juhasova, J., Juhas, S., Motlik, J., Platoshyn, O., Galik, J., Hefferan, M., Yuan, S. H., Vidal, J. G., Carson, C. T., van Gorp, S., Goldberg, D., Leerink, M., Lazar, P., Marsala, S.,

Journal:

Cell Transplantation

Year:

2012

Language:

english

File:

PDF, 1.62 MB

english, 2012

13

Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels

Firth, Amy L., Remillard, Carmelle V., Platoshyn, Oleksandr, Fantozzi, Ivana, Ko, Eun A., Yuan, Jason X.-J.

Journal:

Pulmonary Circulation

Year:

2011

Language:

english

File:

PDF, 2.49 MB

english, 2011

14

Activation of K + channels and increased migration of differentiated intestinal epithelial cells after wounding

Rao, Jaladanki N., Platoshyn, Oleksandr, Li, Li, Guo, Xin, Golovina, Vera A., Yuan, Jason X.-J., Wang, Jian-Ying

Journal:

AJP Cell Physiology

Year:

2002

Language:

english

File:

PDF, 664 KB

english, 2002

15

Anorexic effect of K + channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells

McDaniel, Sharon S., Platoshyn, Oleksandr, Yu, Ying, Sweeney, Michele, Miriel, Victor A., Golovina, Vera A., Krick, Stefanie, Lapp, Bethany R., Wang, Jian-Ying, Yuan, Jason X.-J.

Journal:

Journal of Applied Physiology

Year:

2001

Language:

english

File:

PDF, 850 KB

english, 2001

16

Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI)

Ying Yu, Oleksandr Platoshyn, Olga Safrina, Igor Tsigelny, Jason X.-J. Yuan, Steven H. Keller

Journal:

Biology of the Cell

Year:

2007

Language:

english

File:

PDF, 469 KB

english, 2007

17

DIVERGENT EFFECTS OF BMP-2 ON GENE EXPRESSION IN PULMONARY ARTERY SMOOTH MUSCLE CELLS FROM NORMAL SUBJECTS AND PATIENTS WITH IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION

Fantozzi, Ivana, Huang, Wei, Zhang, Jifeng, Zhang, Shen, Platoshyn, Oleksandr, Remillard, Carmelle V., Thistlethwaite, Patricia A., Yuan, Jason X.-J.

Journal:

Experimental Lung Research

Year:

2005

Language:

english

File:

PDF, 3.59 MB

english, 2005

18

Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents

Ekhterae, D., Platoshyn, O., Zhang, S., Remillard, C. V., Yuan, J. X.-J.

Journal:

AJP Cell Physiology

Year:

2003

Language:

english

File:

PDF, 755 KB

english, 2003

19

Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells

Wu, W., Platoshyn, O., Firth, A. L., Yuan, J. X.-J.

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2007

Language:

english

File:

PDF, 797 KB

english, 2007

20

Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension

Remillard, C. V., Tigno, D. D., Platoshyn, O., Burg, E. D., Brevnova, E. E., Conger, D., Nicholson, A., Rana, B. K., Channick, R. N., Rubin, L. J., O'Connor, D. T., Yuan, J. X.-J.

Journal:

AJP Cell Physiology

Year:

2006

Language:

english

File:

PDF, 1.05 MB

english, 2006

21

Ca 2+ -RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration

Rao, Jaladanki N., Li, Li, Golovina, Vera A., Platoshyn, Oleksandr, Strauch, Eric D., Yuan, Jason Xiao-Jian, Wang, Jian-Ying

Journal:

American journal of physiology. Cell physiology

Year:

2001

Language:

english

File:

PDF, 935 KB

english, 2001

22

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

Arnold, E. S., Ling, S.-C., Huelga, S. C., Lagier-Tourenne, C., Polymenidou, M., Ditsworth, D., Kordasiewicz, H. B., McAlonis-Downes, M., Platoshyn, O., Parone, P. A., Da Cruz, S., Clutario, K. M., Sw

Journal:

Proceedings of the National Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 3.39 MB

english, 2013

23

Overexpression of human KCNA5 increases IK(V) and enhances apoptosis

Brevnova, E. E., Platoshyn, O., Zhang, S., Yuan, J. X.-J.

Journal:

AJP Cell Physiology

Year:

2004

Language:

english

File:

PDF, 511 KB

english, 2004

24

Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways

Steven H. Keller, Oleksandr Platoshyn, Jason X. -J. Yuan

Journal:

Cell Biochemistry and Biophysics

Year:

2005

Language:

english

File:

PDF, 447 KB

english, 2005

25

Cytochrome c activates K + channels before inducing apoptosis

Platoshyn, Oleksandr, Zhang, Shen, McDaniel, Sharon S., Yuan, Jason X.-J.

Journal:

AJP Cell Physiology

Year:

2002

Language:

english

File:

PDF, 348 KB

english, 2002

26

Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca 2+ entry

Kunichika, Naomi, Yu, Ying, Remillard, Carmelle V., Platoshyn, Oleksandr, Zhang, Shen, Yuan, Jason X.-J.

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2004

Language:

english

File:

PDF, 510 KB

english, 2004

27

Neuron-targeted caveolin-1 improves neuromuscular function and extends survival in an SOD1 G93A mice

Sawada, Atsushi, Wang, Shanshan, Jian, Minyu, Leem, Joseph, Wackerbarth, Jesse, Egawa, Junji, Schilling, Jan M., Platoshyn, Oleksandr, Zemljic-Harpf, Alice, Roth, David M., Patel, Hemal H., Patel, Piy

Journal:

The FASEB Journal

Year:

2019

Language:

english

File:

PDF, 1.98 MB

english, 2019

28

Inhibition of K+ Channel Activity in Human Pulmonary Artery Smooth Muscle Cells by Serum from Patients with Pulmonary Hypertension Secondary to Congenital Heart Disease

Limsuwan, Alisa, Platoshyn, Oleksandr, Yu, Ying, Rubin, Lewis J, Rothman, Abraham, Yuan, Jason X-J

Journal:

Pediatric Research

Year:

2001

Language:

english

File:

PDF, 896 KB

english, 2001

29

Hypoxia increases AP-1 binding activity by enhancing capacitative Ca 2+ entry in human pulmonary artery endothelial cells

Fantozzi, Ivana, Zhang, Shen, Platoshyn, Oleksandr, Remillard, Carmelle V., Cowling, Randy T., Yuan, Jason X.-J.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2003

Language:

english

File:

PDF, 797 KB

english, 2003

30

Neuron-targeted caveolin-1 improves neuromuscular function and extends survival in an SOD1 G93A mice

Sawada, Atsushi, Wang, Shanshan, Jian, Minyu, Leem, Joseph, Wackerbarth, Jesse, Egawa, Junji, Schilling, Jan M., Platoshyn, Oleksandr, Zemljic-Harpf, Alice, Roth, David M., Patel, Hemal H., Patel, Piy

Journal:

The FASEB Journal

Year:

2019

File:

PDF, 1.98 MB

2019

31

p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction

Xu, M., Remillard, C. V., Sachs, B. D., Makino, A., Platoshyn, O., Yao, W., Dillmann, W. H., Akassoglou, K., Yuan, J. X.-J.

Journal:

AJP Heart and Circulatory Physiology

Year:

2008

Language:

english

File:

PDF, 1.04 MB

english, 2008

32

Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels

Schach, C., Xu, M., Platoshyn, O., Keller, S. H., Yuan, J. X.-J.

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2006

Language:

english

File:

PDF, 750 KB

english, 2006

33

Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs

Strnadel, Jan, Carromeu, Cassiano, Bardy, Cedric, Navarro, Michael, Platoshyn, Oleksandr, Glud, Andreas N., Marsala, Silvia, Kafka, Jozef, Miyanohara, Atsushi, Kato, Tomohisa, Tadokoro, Takahiro, Heff

Journal:

Science Translational Medicine

Year:

2018

Language:

english

File:

PDF, 18.68 MB

english, 2018

34

Activation of K + channels induces apoptosis in vascular smooth muscle cells

Krick, Stefanie, Platoshyn, Oleksandr, Sweeney, Michele, Kim, Hyong, Yuan, Jason X.-J.

Journal:

American journal of physiology. Cell physiology

Year:

2001

Language:

english

File:

PDF, 1.06 MB

english, 2001

35

Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia

T. Fuchigami, O. Kakinohana, M.P. Hefferan, N. Lukacova, S. Marsala, O. Platoshyn, K. Sugahara, T.L. Yaksh, M. Marsala

Journal:

Year:

2011

Language:

english

File:

PDF, 3.05 MB

english, 2011

36

Subpial Adeno-associated Virus 9 (AAV9) Vector Delivery in Adult Mice

Tadokoro, Takahiro, Miyanohara, Atsushi, Navarro, Michael, Kamizato, Kota, Juhas, Stefan, Juhasova, Jana, Marsala, Silvia, Platoshyn, Oleksandr, Curtis, Erik, Gabel, Brandon, Ciacci, Joseph, Lukacova,

Journal:

Journal of Visualized Experiments

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

37

Thoracic 9 Spinal Transection-Induced Model of Muscle Spasticity in the Rat: A Systematic Electrophysiological and Histopathological Characterization

Corleto, Jose A., Bravo-Hernández, Mariana, Kamizato, Kota, Kakinohana, Osamu, Santucci, Camila, Navarro, Michael R., Platoshyn, Oleksandr, Cizkova, Dasa, Lukacova, Nadezda, Taylor, Julian, Marsala, M

Journal:

Year:

2015

Language:

english

File:

PDF, 15.87 MB

english, 2015

38

Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca 2+ entry

Kunichika, Naomi, Yu, Ying, Remillard, Carmelle V., Platoshyn, Oleksandr, Zhang, Shen, Yuan, Jason X.-J.

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2004

File:

PDF, 510 KB

2004

39

Augmented K + currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis

Krick, Stefanie, Platoshyn, Oleksandr, McDaniel, Sharon S., Rubin, Lewis J., Yuan, Jason X.-J.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2001

Language:

english

File:

PDF, 946 KB

english, 2001

40

Effect of Inorganic and Organic Tin Compounds on ACh- and Voltage-Activated Na Currents

János Györi, Olexandr Platoshyn, David O. Carpenter, János Salánki

Journal:

Cellular and Molecular Neurobiology

Year:

2000

Language:

english

File:

PDF, 137 KB

english, 2000

41

Role of capacitative Ca 2+ entry in bronchial contraction and remodeling

Sweeney, Michele, McDaniel, Sharon S., Platoshyn, Oleksandr, Zhang, Shen, Yu, Ying, Lapp, Bethany R., Zhao, Ying, Thistlethwaite, Patricia A., Yuan, Jason X.-J.

Journal:

Journal of Applied Physiology

Year:

2002

Language:

english

File:

PDF, 302 KB

english, 2002

42

Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension

Yu, Y., Fantozzi, I., Remillard, C. V., Landsberg, J. W., Kunichika, N., Platoshyn, O., Tigno, D. D., Thistlethwaite, P. A., Rubin, L. J., Yuan, J. X.-J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2004

Language:

english

File:

PDF, 529 KB

english, 2004

43

Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes

Zemljic-Harpf, A. E., Godoy, J. C., Platoshyn, O., Asfaw, E. K., Busija, A. R., Domenighetti, A. A., Ross, R. S.

Journal:

Journal of Cell Science

Year:

2014

Language:

english

File:

PDF, 4.76 MB

english, 2014

44

Upregulated TRP and enhanced capacitative Ca 2+ entry in human pulmonary artery myocytes during proliferation

Golovina, Vera A., Platoshyn, Oleksandr, Bailey, Colleen L., Wang, Jian, Limsuwan, Alisa, Sweeney, Michele, Rubin, Lewis J., Yuan, Jason X.-J.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2001

Language:

english

File:

PDF, 732 KB

english, 2001

45

Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation

Platoshyn, Oleksandr, Golovina, Vera A., Bailey, Colleen L., Limsuwan, Alisa, Krick, Stefanie, Juhaszova, Magdalena, Seiden, Jan E., Rubin, Lewis J., Yuan, Jason X.-J.

Journal:

American journal of physiology. Cell physiology

Year:

2000

Language:

english

File:

PDF, 601 KB

english, 2000

46

Capacitative Ca 2+ entry in agonist-induced pulmonary vasoconstriction

McDaniel, Sharon S., Platoshyn, Oleksandr, Wang, Jian, Yu, Ying, Sweeney, Michele, Krick, Stefanie, Rubin, Lewis J., Yuan, Jason X.-J.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2001

Language:

english

File:

PDF, 418 KB

english, 2001

47

Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells

Zhang, Shen, Fantozzi, Ivana, Tigno, Donna D., Yi, Eunhee S., Platoshyn, Oleksandr, Thistlethwaite, Patricia A., Kriett, Jolene M., Yung, Gordon, Rubin, Lewis J., Yuan, Jason X.-J.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2003

Language:

english

File:

PDF, 951 KB

english, 2003

48

Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice

Makino, A., Platoshyn, O., Suarez, J., Yuan, J. X.-J., Dillmann, W. H.

Journal:

AJP Cell Physiology

Year:

2008

Language:

english

File:

PDF, 1.75 MB

english, 2008

49

Time-dependent, bidirectional, anti- and pro-spinal hyper-reflexia and muscle spasticity effect after chronic spinal glycine transporter 2 (GlyT2) oligonucleotide-induced downregulation

Kamizato, Kota, Marsala, Silvia, Navarro, Michael, Kakinohana, Manabu, Platoshyn, Oleksandr, Yoshizumi, Tetsuya, Lukacova, Nadezda, Wancewicz, Ed, Powers, Berit, Mazur, Curt, Marsala, Martin

Journal:

Experimental Neurology

Year:

2018

Language:

english

File:

PDF, 2.23 MB

english, 2018

50

Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity

Kakinohana, Osamu, Hefferan, Michael P., Miyanohara, Atsushi, Nejime, Tetsuya, Marsala, Silvia, Juhas, Stefan, Juhasova, Jana, Motlik, Jan, Kucharova, Karolina, Strnadel, Jan, Platoshyn, Oleksandr, La

Journal:

Year:

2012

Language:

english

File:

PDF, 4.66 MB

english, 2012

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